As with any medication, Zepbound comes with potential side effects. Some common side effects include nausea, diarrhea, and abdominal discomfort, which generally subside over time as the body adjusts to the medication. Serious side effects are rare but can include thyroid tumors, pancreatitis, and kidney issues. Patients with a history of thyroid cancer or certain endocrine disorders should avoid Zepbound.

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